Conservation management for amphibians has increasingly recognised the potential of exploiting environmental mismatches in systems where the invasive pathogen Batrachochytrium dendrobatidis (Bd) has led to declines. The provision of artificial disease refugia, such as habitat manipulations that increase basking opportunities and create saline environments, has been shown to improve survival outcomes in laboratory and mesocosm studies, yet they lack real-world validation. Here, we aimed to explicitly test whether such refugia would be used by, and benefit, frogs susceptible to disease in an unrestricted landscape. In tandem with a broader scale reintroduction program within the ACT, we constructed 12 thermal hotspot structures (to provide thermal refuge) and 4 salted ‘satellite ponds’ (to provide saline refuge) and released twenty-four Green and Golden Bell frogs (Ranoidea aurea), a species that is locally extinct due to Bd. Frogs were fitted with temperature-sensitive radio transmitters and tracked for a period up to 4 months post-release. Through radio telemetry, in tandem with temperature data-loggers spread throughout the wetland, we characterised the microhabitats (both natural and artificial) and thermal profiles used by frogs, and linked these data to disease outcomes through regular swabbing of tracked frogs for Bd. This study provides the first evidence for the utility of disease refugia in real-world settings and will directly inform future translocation and conservation efforts to mitigate the impacts of chytridiomycosis.